PDF] Oxidized cholesterol in the diet accelerates the development of  atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice-  Semantic Scholar

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The goal of the present study was to determine whether oxidized cholesterol in the diet plan speeds up atherosclerosis in low density lipoprotein receptor- (LDLR) and apolipoprotein E- (apo E) lacking mice. Mice were fed either a control diet plan or a diet plan containing oxidized cholesterol. For LDLR-deficient mice, the control diet plan included regular mouse chow to which 1. 0% cholesterol was added. The oxidized diet plan corresponded the control diet plan other than that 5% of the added cholesterol was oxidized. In  This Author -deficient mice, the control diet plan included 0. 15% cholesterol, whereas in the oxidized diet, 5% of the included cholesterol was oxidized.

The Oxidized Cholesterol Strategy by Scott Davis

In mice fed the oxidized-cholesterol diet plans, the levels of oxidized cholesterol in sera were increased. At the end of the experiment, aortas were eliminated and atherosclerosis was assessed. We found that in LDLR-deficient mice, feeding of an oxidized-cholesterol diet resulted in a 32% boost in fatty streak lesions (15. 93+/ -1. 59% versus 21. 00+/ -1. 38%, P.